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Notably, two of the most important transcription factors coactivated by PGC-1 are Nrf2 (Nuclear Factor E2-Related Factor 2) and LXRs (Liver X Receptors) 16

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Our multi-layer approach included functional metabolic assays, mitochondrial morphological evaluation, as well as bulk and single cell proteomic assays to elucidate the immunometabolic features of pre- and post-infusion CD19-CAR T cells

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