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(PubMed) Further, in a myocardial infarction model in rats, semaglutide treatment reduced body-weight, bloodglucose and lipid levels, improved left ventricular ejection fraction, reduced myocardial fibrosis, and altered myocardial metabolism (via untargeted metabolomics) to reflect beneficial remodeling of amino sugar/nucleotide sugar, lipid and organic acid pathways
PMID: 42157826 Exp Biol Med Glucagon-like peptide-1 receptor pathway inhibits extracellular matrix production by mesangial cells through store-operated Ca2+ channel
Rather than chasing duration, use the talk-test to guide intensity: Steady-state cardio that allows short-sentence speech preserves fuel for strength work on the same day
The caveat that matters in TRIUMPH-3 A secondary analysis found no statistically significant reduction in major cardiovascular events compared with placebo
(PubMed) Schmitt JA, Benton D, Kallus KW
It stimulates insulin secretion from pancreatic beta cells in a glucose-dependent manner, meaning it only promotes insulin release when blood sugar levels are elevated
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