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Stacked on top of insulin or a sulfonylurea it can, and the lever is de-intensifying that background drug, not lowering the tirzepatide dose. Over-loss in low-BMI deep responders Across the obesity trials, about 7% of participants fell below a BMI of 22, some by week 12
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Other patients in Illinois and North Carolina were hospitalized following injections.
With combined activation (CagriSema) the effect does not add linearly, but supra-additively , which is why the combination has a stronger clinical result than either component alone
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