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(27) The study demonstrated that GLP-1 use was associated with a significantly lower risk of DFU compared to insulin (HR: 0.44, 95% CI: 0.320.60) for short-term use (400 days) and long-term use (HR: 0.74, 95% CI: 0.600.92)

Some providers use a slower escalation (six weeks per step instead of four) for patients who are more GI-sensitive

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Could affect oral birth control: Since GLP-1 medications can slow digestion, they may affect how oral birth control pills are absorbed

Research studies reflect that 30% to 50% of patients experience gastrointestinal adverse effects with oral semaglutide or Rybelsus