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Diet-induced lethality due to deletion of the Hdac3 gene in heart and skeletal muscle
In addition, NNMTi promotes the secretion of antiinflammatory lipids (such as PAHSA) by adipocytes, further relieving adipose inflammation and improving metabolic function
It binds to GLP-1 receptors on pancreatic beta cells, increasing glucose-dependent insulin secretion while suppressing glucagon from alpha cells
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However, they operate through distinct receptors and second messenger systems
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