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A Phase 2 randomised controlled trial published in The New England Journal of Medicine in 2023 (Jastreboff et al.) enrolled 338 adults with obesity and reported mean body weight reductions of up to approximately 24% over 48 weeks at the highest dose studied (12 mg weekly)
To assess risk variation over time, we stratified the analyses on 0-1 year and 0-3 years by splitting the data on follow up time
GLP-1 receptors are expressed in various tissues and organs including liver, kidneys, peripheral and central nervous system, endocrine glands, skeletal muscles and epicardial adipose tissue
Does IGF-1 make you bigger
The additional GIP receptor activation contributes to its overall efficacy profile
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