Combinatorial therapies with IDO inhibitors and cancer vaccines have also shown progress
Prx3 homodimer has a redox-sensitive cysteine that upon reaction with H 2 O 2 is oxidized to Cys-SOH, which then reacts with neighboring Cys-SH of the other subunit to form an intermolecular disulfide that can be readily reduced by thioredoxin reductase 2 (TrxRD2
GSH-conjugates of AQ-QI and DEAQ-QI were analyzed and quantified by HPLC-UV, as described previously ( Assessment of Cellular GSH and GSSG Content To investigate the GSH and GSSG content in GSTP1 - and mock-transfected HepG2 cells, concentrations of total GSH and GSSG were measured using the GSH/GSSG-Glo TM Glutathione Assay kit (Promega, Madison, WI, United States)
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