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[45] Contraindications [edit] A hormonal IUD should not be used by people who: Are, or think they may be, pregnant [24] Have abnormal vaginal bleeding that has not been explained [24] (controversial) [46] Have untreated cervical or uterine cancer [24] Have, or may have, breast cancer [24] Have abnormalities of the cervix or uterus [47] (controversial) [46] Have had pelvic inflammatory disease within the past three months [24] Have had an STI such as chlamydia or gonorrhea within the past three months [24] Have liver disease or tumor [47] Have an allergy to levonorgestrel or any of the inactive ingredients included in the device [47] Insertion of an IUD is acceptable after a dilation and evacuation (D&E) abortion (second-trimester abortion), but may be associated with a higher expulsion rate
SSRN2023 Nov 17
Safety and Efficacy Two essentials that the medication must have
The published sequence is Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val (one-letter: GEPPPGKPADDAGLV)
The half life for these drugs (how long they last) is 5-7 days, compared to your natural GLP-1 hormone, which lasts a matter of minutes
Tirzepatide has been studied across a wide range of body weights (from 40 kg to over 200 kg), with only minor differences in exposure that are not clinically significant enough to warrant dose modifications
