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Pharmacokinetics Median t max,semaglutide was 1.5 hours for both water volumes with a range of 0.5-3.0 hours for 50 mL and a range of 0.5-4.0 hours for 240 mL

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One caveat specific to retatrutide is the observed transient increase in heart rate , which rose early, peaked around week 24, and then declined over the remainder of the phase 2 trial