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Effect of liraglutide 3.0 Mg in individuals with obesity and moderate or severe obstructive sleep apnea: the SCALE sleep apnea randomized clinical trial

[Published online July 9, 2025] European Medicines Agency

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IGF-1 LR3 is engineered with an N-terminal extension and Arg3 substitution that reduces IGFBP-3 binding, extending its effective activity substantially longer in preclinical models