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MPP + is toxic to neurons by inhibiting mitochondrial complex 1 of the electron transport chain, which results in the generation of excessive reactive oxygen species and cell death
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These 5 residues bind glutathione (GSH) and are only present in GPx1
F., Bergman, B
Most events were mild to moderate and occurred during dose escalation
BPC-157 is derived from a larger protective protein found in human gastric juice, but the isolated 15-amino acid fragment itself is synthetically produced for research purposes
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