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Potential risks include nausea and vomiting, diarrhea or constipation, stomach pain and indigestion, injection site reactions, and a decreased appetite

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Patients with Renal Impairment: Tirzepatide is associated with gastrointestinal ADRs, including nausea, vomiting, and diarrhea leading to dehydration, which can cause acute kidney injury

Pre-dosing with 2550mg diphenhydramine (Benadryl) 30 minutes before injection blunts histamine-mediated flushing and reduces nausea by approximately 40% in clinical observation, though this adds drowsiness that may interfere with morning productivity

He also notes regurgitation and a feeling of food being stuck before passing

CARNITENE 1 g/5 ml solution for injection for intravenous use