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Oral bioavailability is expected to be negligible given the peptide's large size, and subcutaneous or intravenous delivery would likely be required for any human application

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Extrapolating a continuous, high-dose copper-complex therapy without this data is hazardous due to the risk of copper accumulation

(87) noted in their review that co-encapsulation systems can mask astringency of different bioactive ingredients and enhance their stability and bioavailability, as well as to maximize the biological function of bioactive ingredients with synergistic effect. Importantly, they emphasized that synchronized release plays a crucial role in achieving these synergistic effects, with combined formulations showing markedly superior efficacy compared to individual components- a point that deserves particular attention (87)

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