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Early prediction of severe acute pancreatitis using machine learning
135 Further, PRAS40 and mTOR also exerts negative feedbacks on proximal insulin signaling, PRAS40 knockdown significantly decreases Akt phosphorylation, mTORC1 binds and inhibits INSR by inducing destabilization of IRS1
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doi: 10.1038/s41514-022-00084-z
Researchers should design their protocols with these differences in mind and avoid making direct comparisons to clinical trial outcomes without appropriate caveats
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