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These reactions produce degradation products that reduce potency and, in some cases, may increase immunogenicity

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Chemosphere 58:11531159 Paetzold SC, Ross NW, Richards RC, Jones M, Hellou J, Bard SM (2009) Up-regulation of hepatic ABCC2, ABCG2, CYP1A1, and GST in multixenobiotic-resistant killifish ( Fundulus heteroclitus ) from the Sydney Tar Ponds, Nova Scotia, Canada

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