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Constipation, interestingly, shows relatively flat rates across doses, with relative risks around 4.17 to 4.41 regardless of dose level

The study also said the patients were less healthy than they were while on the medication

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Lizcano, 2022)

Primary risks include additive cardiovascular effects (increased heart rate and blood pressure), intensified gastrointestinal symptoms (nausea, vomiting, diarrhea), and potential for serious adverse events including pancreatitis and acute kidney injury requiring close monitoring

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