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In the SURPASS trials in Type 2 diabetes (the evidence behind Mounjaro), nausea ran 1218%, diarrhea 1217%, constipation 67%, vomiting 59%, dyspepsia 58%, and fatigue 46%
In diabetes, there is an accumulation of advanced glycation end products (AGEs) that act like shrapnel going through the kidneys and damaging the tissue
Temperature consistency matters more than absolute temperature within the recommended range
However, prevention through proper nutrition during weight loss therapy is far more effective than managing active shedding
doi:10.1001/jama.2024.10333 2