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Changes in metabolic and endocrine variables in response to exercise and 5R inhibition The metabolic and endocrine variables were measured at the end of the experiment in the CO, PS, PS + RI, PS + R2I, PE, PE + RI and PE + R2I groups

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While no remarkable differences were observed between patient-derived and normal intestinal or kidney organoids, liver organoids from the patient displayed mesenchymal features, including increased expression of COL1A1 , VIM , and ACTA2 , and decreased EPCAM and ECAD expression

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