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8 weeks) in C57BL/6 produces pericentral HSC activation, collagen I/III deposition (Sirius Red staining), and biochemical hepatitis (ALT, AST elevation)

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(4) Johansen PB, Nowak J, Skjaerbaek C, Flyvbjerg A, Andreassen TT, Wilken M, Orskov H

Clinical and biochemical effects

That makes vial duration a dosing-math question rather than a cycle-length question