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The UPenn researchers noted that the hypothalamus, which GLP-1 medications interact with, plays a role in regulating body temperature alongside appetite and hormone function
To assess glucose tolerance, mice were fasted for 16 h overnight
Tirzepatide is already approved and available through proper medical channels
This bidirectional regulation suggests that the two systems evolved to work together, and that disrupting one (as happens in menopause) impairs the other
The timeline for any such changes would typically follow substantial weight reduction, which may take several months of GLP-1 treatment
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