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Ongoing Monitoring At Each Follow-Up Visit: Ask specifically about tingling, numbness, burning sensations Check sensation in hands and feet Document any new symptoms Assess impact on quality of life Consider Dose Reduction If: Mild dysesthesia present but tolerable Patient achieving good weight loss (can afford slightly less efficacy) Symptoms are bothersome but not severe Consider Discontinuation If: Moderate to severe dysesthesia Progressive symptoms despite dose reduction Functional impairment Patient preference to stop Long-Term Unknowns and Research Needs Critical Questions for Future Studies 1

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Vials, syringes, and accessories are shown for illustrative purposes and are not included.

Altered sciatic nerve fiber morphology and endoneural microvessels in mouse models relevant for obesity, peripheral diabetic polyneuropathy, and the metabolic syndrome

This connection signals the melanocytes to increase melanin synthesis