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Patients should be advised to contact their GP if constipation persists despite these measures

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Monitoring parameters should include: Baseline and periodic assessment of renal function, as gastrointestinal side effects may lead to dehydration and acute kidney injury Blood glucose monitoring in diabetic patients, with adjustment of concomitant diabetes medications as needed Weight and nutritional status to ensure weight loss remains within healthy parameters MS symptom stability and functional status Patients should be advised to seek immediate medical attention for severe persistent abdominal pain (possible pancreatitis), signs of thyroid nodules, or symptoms of acute gallbladder disease

A nine-week, randomized, controlled trial of healthy, resistance-trained men found that HMB supplementation had a clear bolstering effect on fat-free mass and substantially strengthened lower-body muscles compared to the placebo group[10]

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