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concurrently, they depend on mitochondria for pregnenolone production, the pivotal precursor of steroid hormones, as well as for the conversion of cholesterol into estrogen and progesterone [43]

Data are shown as means standard errors (SE)

[8] Exogenous testosterone is teratogenic, capable of inducing virilisation of a female fetus when administered during pregnancy

Cravings are at a minimum as well

Induction of rat hepatic and intestinal glutathione s-transferases and glutathione by dietary naturally-occurring anticarcinogens

In summary, PGC-1 emerges as the pivotal regulator in orchestrating the transcriptional cascades of mitochondrial biogenesis and modulating the expression level or activation degree of PGC-1 represents a potent strategy to finely regulate the intricate process of mitochondrial biogenesis