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After 64 weeks, people on the Wegovy pill lost an average of 13.6 percent of their starting body weight, compared with 2.2 percent for the placebo

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This may be due to the limited temporal window of our MRS measurements or could indicate that downstream mechanisms, such as AMPA receptor activation, neuroplastic signaling pathways (for example, BDNF or TrkB and ERK or mTOR) or effects in regions beyond the ACC, are more critical targets for mediating antidepressant response