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Common side effects Most side effects involve the stomach, tend to be mild to moderate, and usually ease as your body adjusts: Nausea Diarrhea Vomiting Stomach pain, bloating, and constipation Indigestion, heartburn (GERD), and burping Headache, dizziness, and tiredness Reduced appetite and weight loss Low blood sugar, mainly when taken with a sulfonylurea or insulin Serious side effects Get medical help right away if you notice any of these: Who should not take semaglutide

Starting with lower doses and gradually increasing can help minimize these early symptoms

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Y., Lee, J