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DPP-4 has been extensively reported to be expressed in the muscular layer of the jejunum and is associated with local levels of NPY family peptides, including neuropeptide Y (NPY), peptide YY (PYY), and pancreatic polypeptide (PP) (Malinauskas et al., 2025)
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Preliminary findings implied that the peptide may have contributed to increased body mass and a probable elevation in the overall tibial and vertebral BMC (bone mineral content) as detected by DEXA compared to the placebo group
Uzlova N, Mnozil Stridova K, Merta D, Rychlik I, Frankova S
Dreher, Gabard, Schwindt, Maibach
These investigations help clarify how integrated incretin and glucagon signaling contributes to the regulation of metabolic energy flux in complex biological systems
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