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Naunyn-Schmiedeberg's Arch Pharmacol
A recent meta-analysis of 14 studies [2] has shown that GLP-1RAs, such as liraglutide, semaglutide, and exenatide, cross the blood-brain barrier (BBB) and affect the brain at all levels, from the molecular to the level of neuronal networks
Another potential question that clinical trials will need to assess is whether GLP-1 drugs are actually safe to take for people without obesity or diabetes, as the weight loss these drugs induce could be a damaging side effect
Among them, GPX1-4 and 6 are selenocysteine-containing proteins
NPJ Aging 8(1):3 Saihara K et al (2017) Pyrroloquinoline quinone, a redox-active o-Quinone, stimulates mitochondrial biogenesis by activating the SIRT1/PGC-1alpha signaling pathway
Thats also how it can seem with FDA-approved GLP-1s weight-loss medications that significantly reduce your appetite and slow digestion
