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Patients should be counseled on warning signs including inability to tolerate oral fluids, decreased urine output, dizziness, or severe abdominal pain, which require immediate medical evaluation rather than dose escalation
Diabetes Care 46(5):9981004
Many patients transition to a maintenance cycle after the initial protocol period, with MOTS-c dosing spaced further apart to sustain the metabolic improvements achieved
Additionally, peptides may have poor oral bioavailability, often requiring specialized delivery methods
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