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GLP1 + Signos starting at $199/mo
Clinical trials vs real-world results What the clinical trials show The landmark SURMOUNT-5 trial published in 2025 compared these medications directly at standard maximum doses: 1 Mounjaro (tirzepatide 15 mg) produced 20.2% average weight loss Wegovy (semaglutide 2.4 mg) produced 13.7% average weight loss The 6.5 percentage point difference was statistically significant This trial used the maximum approved doses at the time (Mounjaro 15 mg, Wegovy 2.4 mg) and lasted 72 weeks
That said, common side effects such as loss of appetite, disordered sleep, or an upset stomach may indirectly make it more difficult to bounce back
Key Takeaways Loose skin after GLP-1related weight loss is common because the skin often cannot adjust as quickly as the body changes
She reports losing about 14 kilograms and hopes sharing her story will help others facing similar struggles
The color should be uniform throughout the vial with no darker spots, streaks, or gradients
