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Table S5
Because GCLC floxed X Iba1-Cre mice died early (around 34 months of age) due to developmental defects, we could not assess the effect of microglial GCLC-deficiency on brain atrophy
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Furthermore, Dihexa decreased the activation of astrocytes and microglia, markedly reduced levels of the pro-inflammatory cytokines IL-1 and TNF- and increased the levels of the anti-inflammatory cytokine IL-10
A randomized, double-blind, placebo-controlled, delayed start study to assess rasagiline as a disease modifying therapy in Parkinsons disease (the ADAGIO study): rationale, design, and baseline characteristics
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