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Coskuns research contributions span the entire development arc of GLP3 : Discovery and initial characterization of GLP3 s triple-receptor agonist properties and pharmacological profile Preclinical studies establishing proof-of-mechanism in mouse models and in vitro receptor systems Design and medical oversight of phase 1b and phase 2 clinical trials in type 2 diabetes and obesity Investigation of GLP3 s effects on gastric emptying and mechanistic studies of weight loss Contribution to over 168 peer-reviewed publications in metabolic disease research with citation impact exceeding 8,700 citations His work extends beyond GLP3 to include fundamental contributions to the development of GLP2 and advancement of incretin-based therapeutics more broadly

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During the first week on GLP-1, a few bites earlier in the day can be gentler than trying to make up for it later

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The activity of the phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt) pathway and the expression of peroxisome proliferator-activated receptor coactivator-1 (PGC-1) were verified by Western blot

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The researchers analyzed data from eight randomized controlled trials involving 8,847 participants, most of whom were women (74%) and had obesity (96%)

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