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[1] This mechanism can have variable effects on IBS symptoms depending on the predominant bowel pattern

doi: 10.1016/J.JTCME.2017.11.004 151 HallWLVafeiadouKHallundJBugelSReimannMKoebnickCet al

From gastrointestinal discomfort to gallbladder risks and pancreatitis concerns, this article explores what we know, what we dont, and how to counsel patients realistically about long-term therapy

6, A399A400

Oral formulations typically show greater first-pass hepatic metabolism and lower peak concentrations, potentially affecting tolerability and efficacy in certain metabolic states

Second, baselines and potential confounders were adjusted to create a robust control group