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Notably, a recent study defined distinct POMC neurons expressing leptin receptor and GLP-1R exhibiting a distinct anatomical distribution and electrophysiological properties [27], suggesting further investigation of the heterogeneous function mediated by these diverse cell types in the ARC is required

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How PT-141 Works MC4R activation PT-141 binds melanocortin-4 receptors (with MC3R activity) in hypothalamic regions - the central hub for sexual motivation circuits

Others can cause insomnia, low appetite and gastrointestinal (GI) issues like nausea and diarrhea, which can indirectly lead to tiredness

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