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When GLP-1 signaling was blocked, TC10's cognitive protective effects were significantly attenuated
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16 Sensitivity analyses showed that variations in cost assumptions, where worst case scenarios for semaglutide (those where the price of this drug was highest and that of dulaglutide was lowest) were considered, did not change the finding that the cost of reaching the composite endpoint with semaglutide was lower than the cost with dulaglutide after one year of treatment, with semaglutide having a cost per patient of $8.151.369, compared to $10.006.649 with dulaglutide, representing an expenditure 22% higher (Figure 4)
Brain dopamine and obesity
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