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This work was supported by the National Institute for Health and Care Research Maudsley Biomedical Research Centre
Key Research Focus Areas Peptide Signaling Research: Investigation of peptide-related biological signaling pathways and cellular response mechanisms
Evidence-based Complement
Ipamorelins selective GHS-R1a agonism drives GH granule exocytosis from somatotrophs through Gq/11-PLC-IP3-calcium mobilisation , the identical intracellular signalling cascade engaged by non-selective first-generation GH secretagogues and but does so without producing the off-target receptor engagement at pituitary lactotrophs and corticotrophs that drives prolactin and cortisol co-secretion following GHRP-6 and GHRP-2 administration
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