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Therefore, ID has widespread and profound effects on T cells, including disrupting energy metabolism, inhibiting the expression of differentiation-related genes, and reducing the production of key cytokines, thereby impairing the immune control over tumors and diminishing the overall effectiveness of immunotherapy

(44) demonstrated that exposure of chicken erythrocytes to the free radical generator 2,2-azobis (2-methylpropionamidine) dihydrochloride (AAPH) resulted in severe hemolysis, decreased SOD activity, and increased malondialdehyde (MDA) levels

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After adjusting for latent confounding covariates, including dietary intake of TMAO precursor choline and betaine, the prospective association was independent of conventional AF risk factors

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