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Summary of recommendations Most scientifically supported for weight loss: Tirzepatide Most accessible: Semaglutide Best non-GLP-1 peptide for moderate weight loss: Tesamorelin In this Review Why you should trust us Over the past two decades, Innerbody Research has helped tens of millions of readers make more informed decisions about staying healthy and living healthier lifestyles

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These estimates address different exposures, populations, outcomes, and study designs, so they should not be treated as one uniform pooled analysis or compared as though they measure the same clinical question

Unlike figure 1, this extends beyond the first AOM named by each doctor to include all AOMs named and is specific to the brand name (apart from for orlistat, where the INN is included)

Discuss whether it is appropriate for your specific situation with a licensed provider before making any treatment decisions

Semaglutide was FDA-approved for weight loss in 2021 and it has been shown to reduce body weight by at least 15% in 8 weeks