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First, the human RCT footprint is thinner than the mechanism literature

Frequency depends on the selected injection, your goals, and provider guidance

(PubMed) Shaw GM, Finnell RH, Blom HJ, et al

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The Phase 2 dose-finding trial (N=338), published in the New England Journal of Medicine in 2023 (DOI: 10.1056/NEJMoa2301972), randomized participants with obesity (BMI 30-50) to retatrutide at doses ranging from 0.5mg to 12mg weekly or placebo over 48 weeks

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