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non-enzymatic actions and the overall significance of DPP-4 for normal physiological regulation in humans and for the pathogenesis of metabolic disease are still largely unknown, targeting the catalytic activity has been harnessed pharmacologically, and DPP-4 inhibitors now play an important part in the therapy of T2DM

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The G s (DNG s with 9 mutations) used to stabilize the tirzepatideGLP-1RG s complex was the same as that employed for the tirzepatideGIPRG s complex

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