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Until further large clinical trials are done to show a definite benefit of GLP1-RA in PWS patients, this cannot at present be recommended as the standard of care, the researchers wrote

Each comes with its own balance of effectiveness and side effect risk

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These drugs are now being prescribed to millions worldwide , making them among the most impactful medical breakthroughs of the decade

Dupilumab blocks IL-4/IL-13 signaling but does not directly repair the skin barrier or restore antimicrobial peptide levels

Oral contraceptives, which interfere with B6 metabolism, have also been associated with low levels