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The medication (a GLP-1 receptor agonist) was initially used to treat diabetes by regulating blood sugar levels

FDA Prescribing Information, WEGOVY (semaglutide) Boxed Warning: Risk of Thyroid C-Cell Tumors (medullary thyroid carcinoma)

The changes observed in photoaged skin include deep wrinkles, sallow discoloration, and irregular pigmentation

Nausea, vomiting, diarrhea, constipation, and abdominal pain were the most common, mostly transient and mild to moderate

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doi: 10.3389/fnbeh.2026.1805953 Received 06 February 2026 Revised 13 March 2026 Accepted 13 March 2026 Published 13 April 2026 Volume 20 - 2026 Edited by Emmanuel Darcq, Institut National de la Sant et de la Recherche Mdicale (INSERM), France Reviewed by Zhe Zhao, Max Planck Florida Institute for Neuroscience (MPFI), United States Madhawi Aldhwayan, King Saud University, Saudi Arabia Updates Copyright 2026 OConnor