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The findings of another prospective study (the Hordaland Health Study) that followed 7,045 healthy adults (ages, 47-49 years and 71-74 years) suggested that high choline and low betaine plasma concentrations were associated with an unfavorable cardiovascular risk profile (51)

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The free energy of a typical reaction is calculated directly from its E o by the Nernst equation as shown below, where n is the number of electrons involved in the reaction and F is the Faraday constant (23.06 kcal/volt/mol or 94.4 kJ/volt/mol): G = nF E o For the oxidation of NADH, the standard biological reduction potential is 52.6 kcal/mole

doi: 10.1073/pnas.94.22.11875 36 McCordJMFridovichI

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