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Functionally, GIP receptor activation improves intracellular Ca 2+ concentration, glucagon secretion, and cell depolarization by increasing cAMP/PKA signaling pathways [75, 76]

In various healthcare settings, acute kidney disease (AKD) has seen a rising incidence, with associated heightened risks of all-cause mortality, end-stage kidney disease, and chronic kidney disease (CKD)

The authors stated that these side effects limited the clinical use of GLP-1 RAs in people with type 1 diabetes

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Open 12 , 100123 (2021)