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The extended half-lives of weekly formulations mean these medications do accumulate to some degree with repeated dosing until reaching what is termed 'steady state'a predictable, stable concentration that optimises therapeutic benefit whilst minimising adverse effects

As blood sugar levels rise after eating, the incretins potentiate glucose-dependent insulin secretion from pancreatic -cells and inhibit glucagon secretion from pancreatic -cells

10.20517/cdr.2019.10 177 WangY.YangL.MaoL.ZhangL.ZhuY.XuY.et al (2022)

Freezing destroys the peptide structure and renders the medication ineffective

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I test, was statistically significant in all subgroup analyses evaluating bowel preparation