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IGF-1 LR3 is a recombinant analog of human IGF-1 with an N-terminal extension and an arginine substitution at position 3, which extends its half-life to 2030 hours compared to endogenous IGF-1s half-life of approximately 10 minutes

PubMed Heffernan, M.A., Thorburn, A.W., Fam, B., Summers, R., Conway-Campbell, B., Waters, M.J., & Ng, F.M

Nutr Metab (Lond) 14 , 7 (2017)

The 1416 region (residues 329456) was poorly resolved at higher contour levels and was modelled based on density observed at lower contour levels (Supplementary Fig

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And unlike steroid hormones, which stay in the body a long time, peptides have a very short half-life, so they have been shown to be extremely safe