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Key genes promoting ROS/RNS production: Thbs1 , S100a8 and Nos2 , were significantly downregulated, while the glutathione S-transferase gene Gsta2 , involved in cellular anti-oxidative defence, was upregulated 36,37

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however, a significant increase in the GR activity was observed from day 15 onward

While some studies have followed patients for several years, longer-term data on safety and efficacy are limited

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