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Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion

Some researchers prefer an alternative method

One of the main obstacles is the need for more reliable behavioral measurements as readouts

According to a 2017 systematic review in the Journal of Clinical Nursing confirming that aspiration before subcutaneous injection does not reduce adverse events, subcutaneous injections carry a distinct pharmacokinetic profile that intramuscular delivery disrupts, which is why correct angle and depth matter for predictable results

doi: 10.1016/j.redox.2016.12.022 69 ChenJZhangSXueXMaXChenAWuYet al