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Recent studies have shown that SIRT1 exerts a neuroprotective effect in MPP+-treated dopaminergic neurons, primarily through deacetylation of PKM2, which improves brain lactate homeostasis and upregulates PGC-1 expression, promoting mitochondrial biogenesis in MPP+-treated cells 8,41

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20 days old flies, Sp and/or L-DOPA fed from 10 days AEL, was used in all the experiments

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(Genome Medicine, 2012) used that dataset to identify GHK as inversely correlated with an emphysema-related lung destruction signature, then examined collagen remodelling in cultured lung fibroblasts