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Resolution of a renal sulfhydryl (glutathione) oxidase from gamma-glutamyltransferase

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Standard Hill-equation pharmacology applied to retatrutides free-drug Cav,ss and the Coskun 2022 cAMP EC50 values (functional potency from low-receptor-density assays, used here as the occupancy denominator an approximation, not a binding constant)

Exogenous MOTS-c supplementation may partially restore this responsiveness

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