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A classic pharmacokinetic study in the Annals of Internal Medicine (Levine et al., 2004) found that a modeled 50 g IV dose produced peak plasma levels around 13,400 mol/L, versus 220 mol/L for the maximum tolerated oral regimen roughly 3070 times higher plasma concentrations with IV administration

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In Metabolic Dysfunction-Associated Steatotic Liver Disease, GLP-1 RAs and GIP/GLP-1 RAs demonstrate marked histological improvements

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The Arg-248 residue in the L3 loop binds the DNA minor groove

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